Depression

Depression

WHAT IS DEPRESSION?

Depression is a mental illness which encompasses a depressed mood or loss of interest or pleasure over a determined period of time, with multiple causes. This results in an impaired function in many different areas of life. The patient may experience a depressed mood or an irritable mood, decreased interest, significant weight change, change in sleep and in activity, fatigue, loss of energy and concentration, guilt or thoughts of suicide.

The brains biochemistry is altered resulting in a change of the concentration of certain neurotransmitters, such as serotonin, norepinephrine and dopamine. These neurotransmitters act in many areas of the brain, but mostly in the Limbic System which acts specifically in the rewarding system of our conduct. On patients going through a depression, this system is drastically altered.

WHICH ARE THE SYMPTOMS OF DEPRESSION?

If you chronically suffer these symptoms for more than two weeks, it is likely that you are experiencing depression:

  • Sadness.

  • Insomnia or excessive sleep.

  • Loss of appetite.

  • Loss of interest for things that usually give pleasure.

  • Lack of interest in sex.

  • Irritability.

  • Difficulty concentrating.

  • Desire to die.

  • Desire to commit suicide.

  • Feelings of guilt.

  • Despair.

  • Inexplicable fear.

  • Shivering, palpitations, sweating.

  • Fatigue or loss of energy.

  • Associated with depression or suicidal thoughts try.

DIFFERENT TREATMENTS FOR DEPRESSION

The most common treatment are prescribed medications.
Electroconvulsive therapy (ECT) is the most effective treatment for depression.

Comparison with other antidepressant treatments.

 Antidepressant medicationElectroconvulsive Therapy (ECT)TMS
Efectividad

Antidepressant medication:

50% or more

Electroconvulsive Therapy (ECT):

80% effectiveness

TMS:

Comparable to ECT
Begining of Therapeutic Effects

Antidepressant medication:

4-6 weeks

Electroconvulsive Therapy (ECT):

1 week

TMS:

1 week
Adverse events

Antidepressant medication:

Headache, dry mouth, dizziness, constipation, nausea, blurred vision, urinary retention, delayed or retrograde ejaculation

Electroconvulsive Therapy (ECT):

Loss of memory, muscular pain, nausea, headache

TMS:

Mild headache that resolves with a single dose of Tylenol
Appearance of Adverse Events

Antidepressant medication:

67% will experience at least one significant adverse event. 80% will have any sort of sexual dysfunction due to medication

Electroconvulsive Therapy (ECT):

Up to 100%

TMS:

10%

TMS FOR DEPRESSION

TMS returns Hope for People Who Have Not Found Effective Solution one depression, the UN helps accelerate change that allows them to regain control of their lives and feel good. The treatment complements the efforts of the patient and medical team, composed of various Health Professionals To enable and accelerate change in a safe, outpatient, and effective.

  • Video from Dr. Oz about treatments for depression.

    View video

  • Download reference Document about TMS and TMS Clinic Latinoamerica.

HOW DOES TMS TREAT DEPRESSION?

TMS or Transcraneal magnetic stimulation uses an electric current that generates a magnetic field, which in return activates neurons. The fundamental principle of TMS is an electromagnetic induction phenomenon to elicit or create a focal stimulation on brain tissue to trigger activation.

This magnetic field crosses the skull and soft surrounding tissue to reach the brain cells, specifically the neural pathways which connect to the limbic system. The limbic system in our brains is in charge of emotion, motivation and pleasure.

Controlled clinical trials have supported the efficacy of this technology, both excitatory rTMS and inhibitory rTMS, both used in different scenarios. One important factor has been the broad concept of brain plasticity which is the capacity of brain tissue to undergo dynamic changes over time, it has been demonstrated that this changes could be structural or functional showing a much higher success rate over time.

HOW LONG DOES IT LAST?

The protocol used in our clinic consists in two daily sessions, each lasting 30 minutes approximately with a short break in-between. Our clinic applies the treatment from Monday through Friday for two consecutive weeks.

Once the two weeks of rTMS are over, each patient is individually evaluated by one of our Psychiatrists to determine and assess the results of the treatment. The treatment can be continued for one more week if it is considered necessary by the patient and the doctor.

In many cases maintenance sessions may be considered necessary, these could be scheduled 6 or 12 months after the initial application.

WHAT ARE THE RESULTS OF THIS TREATMENT FOR PEOPLE WITH DEPRESSION?

Transcraneal Magnetic Stimulation has proven to have great results in comparison to other types of treatment, such us medication view treatments table, electroconvulsive therapy and vagus nerve stimulation.

Safety and tolerability of every treatment is regularly taken into consideration in clinical trials and therapeutic interventions; in this context, TMS appears to be relatively safe and a well tolerable treatment. The most common problem includes application pain or discomfort on the application site, however if this occurs, the patient rapidly acclimates in a short period of time.

One of the most important advantages of TMS is the evident rapid results and the effectiveness of this treatment. Clinical investigation shows up to an 80% of improvement and durability of antidepressant benefits time after a successful TMS application. In some cases the utilization of only TMS for acute and maintenance purposes may be a functional strategy.

CANDIDATES FOR TMS

WHICH PATIENTS ARE CANDIDATES TO RECEIVE TMS?

TMS has proven to be effective in treating the following neuropsychiatric disorders:

  • First choice for all types of depression.

  • Depression resistant to treatment by antidepressant medications.

  • Bipolar Disorder.

  • Depression in patients intolerant to antidepressant medications due to hypersensitivity or adverse side effects (weight gain, decreased libido or sex drive, tremors, dry mouth).

  • Depression in patients with other indispositions. For example heart conditions that prevent the use of antidepressant medication.

  • Post-partum depression.

  • In cases where Electroconvulsive therapy has been prescribed by a Psychiatrist.